Table 2.

Effects of type 1 diabetes on longitudinal trajectories of axial diffusivity, fractional anisotropy, mean diffusivity and radial diffusivity using mixed effects modelling

Comparison	Axial diffusivity (10−3 mm2/s)		Fractional anisotropy (×1000)		Mean diffusivity (10−3 mm2/s)		Radial diffusivity (10−3 mm2/s)
	Estimate	p value	Estimate	p value	Estimate	p value	Estimate	p value
Baseline vs 18 months
Diabetes group	−0.003	0.107	6.922	<0.001	−0.007	<0.001	−0.009	<0.001
Control group	−0.003	0.194	4.965	0.003	−0.005	0.004	−0.006	0.002
Diabetes vs without diabetes
At baseline	−0.008	0.022	−1.612	0.582	−0.004	0.194	−0.002	0.563
At 18 months	−0.008	0.015	0.346	0.905	−0.006	0.070	−0.005	0.207
Effect on slope	0.000	0.982	1.957	0.325	−0.002	0.403	−0.003	0.271
Baseline age effect
At baseline	−0.004	<0.001	5.648	<0.001	−0.007	<0.001	−0.008	<0.001
At 18 months	−0.004	<0.001	3.319	<0.001	−0.005	<0.001	−0.005	<0.001
Effect on slope	0.000	0.971	−2.329	<0.001	0.002	0.003	0.003	<0.001
Sex effect
At baseline	−0.006	0.082	−2.289	0.419	−0.002	0.555	0.000	0.962
At 18 months	−0.006	0.052	0.430	0.878	−0.004	0.181	−0.003	0.401
Effect on slope	0.000	0.906	2.719	0.144	−0.002	0.328	−0.003	0.200

Estimates of effect are shown with corresponding p values

Within and between-group comparisons were made. Baseline age effect and sex effect at baseline and 18 months were also assessed, as was effect on slope (change from baseline to 18 months for baseline age and sex)