Fig 2. Crystal structures of apo-PTK6 and PTK6 complexes with inhibitors.

(A) Apo-PTK6 crystal structure (shown in orange) with Y342 phosphorylated overlaid with the published structure by Thakur et al (28) (shown in green); (B) Active site structure of PTK6 in complex with the Type I inhibitor 21c; (C) Active site structure of PTK6 in complex with the Type II inhibitor PF-6683324. Asp330 and Phe331 belong to the DFG-motif of PTK6.