Table 1.
Reduction in Viable Tumor by Treatment with Decapping-Deficient VACV
| Treatment Group | Mouse # | Tumor Necrosis | Residual Viable Tumor (HCC) (%) |
|---|---|---|---|
| Mock | 61 | yes | 50 |
| Mock | 64 | yes | 50 |
| Mock | 65 | yes | 45 |
| ΔD9 | 67 | yes | 0 |
| ΔD9 | 69 | yes | 4 |
| ΔD10 | 51 | yes | 3 |
| ΔD10 | 52 | yes | 3 |
On day 17 (mouse #67 and #69) or day 20 (mouse #51, #52, #61, #64, and #65), animals treated as in Figure 4 were sacrificed and explanted tumors were fixed in formalin. Paraffin-embedded sections were prepared and stained with H&E and evaluated by light microscopy.