Table 4.

Comparison of G2, WD-G3, and PD neuroendocrine neoplasm cytologic features

	Well differentiated G2	Well differentiated G3	Poorly differentiated	P value
Total (n=65)	19	32	14
Ki67% median (range)	11% (3.2–17)	40% (21–89)	62% (25–95)	<.001
Large nuclear size No. (%)	0 (0)	3 (9)	2 (14)	.2
Nuclear pleomorphism No. (%)	1 (5)	4 (13)	7 (50)	.004
Round nucleus No. (%)	14 (74)	19 (59)	3 (21)	.01
Smooth nucleus contour No. (%)	18 (95)	30 (94)	9 (64)	.02
Angulated nuclei No. (%)	3 (21)	12 (38)	12 (87)	<.001
Fine chromatin No. (%)	3 (15)	3 (4)	1 (7)	.8
Single prominent nucleolus No. (%)	1 (5)	4 (13)	2 (14)	.6
Plasmacytoid morphology No. (%)	16 (84)	24 (75)	1 (7)	<.001
Abundant cytoplasm No. (%)	11 (17)	23 (72)	3 (21)	.007
Nuclear tangles No. (%)	8 (42)	24 (75)	13 (93)	.006
Molding No. (%)	1 (5)	3 (9)	11 (79)	<.001
Apoptosis No. (%)
Present	11 (58)	28 (86)	14 (100)	.005
>5/ 10 hpf	3 (18)	14 (44)	11 (79)	.001
Mitoses No. (%)
Present	10 (27)	18 (56)	9 (64)	.8
>5/10 hpf	1 (5)	6 (3)	6 (43)	.03
Necrosis	0 (0)	4 (13)	6 (43)	.003