Table 6.
Morphologic features and Ki67 proliferation rate for poorly differentiated neuroendocrine carcinoma subtypes
| Small cell | Large cell | Type not otherwise specified |
P-value1 | |
|---|---|---|---|---|
| Total (n=15) | 6 | 5 | 3 | |
| Ki67% median (range) | 80%(63–95) | 45% (25–61) | 70% (30–80) | .003 |
| Large nuclear size No. (%) | 0 | 2 (40) | 0 | |
| Nuclear pleomorphism No. (%) | 2 (33) | 4 (80) | 2 (67) | |
| Round nucleus shape No. (%) | 0 | 2 (40) | 1 (33) | |
| Smooth nucleus contour No. (%) | 2 (40) | 4 (67) | 2 (67) | |
| Angulated nuclei No. (%) | 6 (100) | 3 (60) | 3 (100) | |
| Fine chromatin No. (%) | 0 (0) | 0 (0) | 1 (33) | |
| Single prominent nucleolus No. (%) | 0 | 2 (40) | 0 | |
| Plasmacytoid cells No. (%) | 0 | 1 (20) | 0 | |
| Abundant cytoplasm No. (%) | 0 | 3 (60) | 0 | |
| Nuclear tangles No. (%) | 6 (100) | 4 (80) | 3 (100) | |
| Molding No. (%) | 6 (100) | 2 (40) | 3 (100) | |
| Apoptosis No. (%) | ||||
| Present | 6 (100) | 5 (100) | 3 (100) | |
| >5/ 10 hpf | 6 (100) | 3 (60) | 2 (100) | |
| Mitoses No. (%) | ||||
| Present | 3 (50) | 3 (60) | 3 (100) | |
| >5/10 hpf | 3 (50) | 2 (40) | 1 (33) | |
| Necrosis | 3 (50) | 3 (60) | 0 (0) |
1
Numbers were too limited to test.