Table 3.
Comparison of levels of immune and angiogenesis factors in stool from PD patients and their spouses separated by sex
| PATIENT IS FEMALE | PATIENT IS MALE | ||||||||
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| Panel | Factor | N | Mean Dif (pg/mg) |
Std Dev | p-value | N | Mean Dif (pg/mg) |
Std Dev | p-value |
| Angiogenesis | Flt1 | 10 | 1.776 | 3.077 | 0.1013 | 29 | −0.3635 | 4.451 | 0.6635 |
| PlGF | 10 | 0.6796 | 0.6393 | 0.0084 | 29 | −0.2227 | 0.9099 | 0.1982 | |
| Tie2 | 10 | 67.79 | 122.3 | 0.1135 | 29 | 2.117 | 168.1 | 0.9464 | |
| VEGF-C | 10 | 70.45 | 102.4 | 0.0575 | 29 | −34.11 | 101.9 | 0.0824 | |
| VEGF-D | 10 | 8.259 | 9.029 | 0.0178 | 29 | −3.290 | 16.87 | 0.3028 | |
| bFGF | 10 | 0.3046 | 0.3821 | 0.0327 | 29 | −0.04650 | 0.7164 | 0.7291 | |
|
| |||||||||
| Chemokine | Eotaxin | 10 | 4.965 | 5.986 | 0.0277 | 29 | −0.6213 | 6.545 | 0.6132 |
| Eotaxin-3 | 10 | 16.56 | 16.12 | 0.0100 | 29 | −7.192 | 30.08 | 0.2084 | |
| IP-10 | 10 | 0.2133 | 0.3305 | 0.0717 | 29 | −0.01270 | 0.4037 | 0.8672 | |
| MCP-1 | 10 | 0.1473 | 0.3382 | 0.2016 | 29 | −0.03700 | 0.2909 | 0.4993 | |
| MCP-4 | 10 | 1.897 | 3.314 | 0.1037 | 29 | −0.7261 | 2.526 | 0.1328 | |
| MDC | 10 | 5.371 | 6.354 | 0.0255 | 29 | −2.534 | 8.185 | 0.1066 | |
| MIP-1α | 10 | 3.501 | 5.582 | 0.0786 | 29 | −0.2698 | 5.443 | 0.7914 | |
| MIP-1β | 10 | 1.538 | 2.092 | 0.0452 | 29 | −0.2347 | 2.189 | 0.5683 | |
| TARC | 10 | 0.3986 | 0.3828 | 0.0093 | 29 | −0.1299 | 0.7797 | 0.3773 | |
|
| |||||||||
| Cytokine | IL-12/23 p40 | 10 | 0.6052 | 1.692 | 0.2874 | 29 | 0.04700 | 2.013 | 0.9007 |
| IL-15 | 10 | 0.3157 | 0.4257 | 0.0437 | 29 | −0.01490 | 0.8733 | 0.9275 | |
| IL-16 | 10 | 14.05 | 18.52 | 0.0399 | 29 | −2.711 | 12.84 | 0.2652 | |
| IL-17A | 10 | 0.5709 | 1.475 | 0.2521 | 29 | −0.02620 | 1.953 | 0.9429 | |
| IL-1α | 10 | 12.97 | 61.82 | 0.5236 | 29 | 165.9 | 569.2 | 0.1277 | |
| IL-5 | 10 | 0.4791 | 0.5910 | 0.0305 | 29 | −0.08360 | 0.7022 | 0.5268 | |
| IL-7 | 10 | 0.1915 | 0.6243 | 0.3573 | 29 | −0.07800 | 0.6125 | 0.4986 | |
| LTA | 10 | 0.1685 | 0.3000 | 0.1095 | 29 | −0.1451 | 0.6120 | 0.2204 | |
| VEGF | 10 | 34.32 | 90.45 | 0.2608 | 29 | 10.35 | 61.63 | 0.3821 | |
|
| |||||||||
| Proinflammatory | IFNγ | 10 | 7.957 | 13.69 | 0.0993 | 29 | 5.571 | 49.55 | 0.5569 |
| IL-10 | 10 | 0.2590 | 1.876 | 0.6726 | 29 | −0.08170 | 3.761 | 0.9093 | |
| IL-13 | 10 | 0.5898 | 2.791 | 0.5208 | 29 | −0.3801 | 1.872 | 0.2922 | |
| IL-1β | 10 | 1.973 | 6.809 | 0.3833 | 29 | 4.587 | 21.70 | 0.2731 | |
| IL-2 | 10 | 0.7725 | 2.373 | 0.3301 | 29 | −1.030 | 4.445 | 0.2307 | |
| IL-4 | 10 | 0.02340 | 0.4506 | 0.8733 | 29 | −0.1984 | 0.9819 | 0.2944 | |
| IL-6 | 10 | 1.885 | 16.49 | 0.7262 | 29 | −1.142 | 4.731 | 0.2124 | |
| IL-8 | 10 | 4.943 | 22.29 | 0.5009 | 29 | 62.76 | 232.9 | 0.1654 | |
| TNF | 10 | 0.04880 | 0.5317 | 0.7782 | 29 | −0.3561 | 1.385 | 0.1848 | |
|
| |||||||||
| Vascular Injury | CRP | 10 | −671.7 | 2062 | 0.3298 | 29 | 933.4 | 4847 | 0.3173 |
| SAA | 10 | 3.567 | 72.14 | 0.8792 | 29 | −1.229 | 110.4 | 0.9534 | |
| sICAM-1 | 10 | 1.930 | 4.425 | 0.2011 | 29 | 9.393 | 44.03 | 0.2689 | |
| sVCAM-1 | 10 | −1.153 | 14.72 | 0.8099 | 29 | −5.996 | 36.20 | 0.3885 | |
Mean difference (patient – control) between analyte levels (pg/mg total protein) with standard deviations
N = number of measurements for each subject group
Gray shading indicates significant (p<0.05) difference between patients and household controls by paired t-test