Table 4.

Association between PD status and levels of stool immune and angiogenesis factors when accounting for potential confounders or effect modifiers

Panel	Factor	Estimate	95% Confidence Limits		p-value
Angiogenesis	Flt1	1.087	−0.01908	2.192	0.0541
	PlGF	1.087	−0.01908	2.192	0.0541
	Tie2	−0.4496	−39.62	38.72	0.9820
	VEGF-C	−9.056	−42.74	24.63	0.5968
	VEGF-D	−1.289	−5.128	2.551	0.5091
	bFGF	0.01910	−0.1271	0.1653	0.7971
Chemokine	Eotaxin	0.1777	−1.476	1.831	0.8325
	Eotaxin-3	0.9905	−4.683	6.663	0.7312
	IP-10	0.02551	−0.08694	0.1380	0.6554
	MCP-1	0.01348	−0.1242	0.1511	0.8471
	MCP-4	0.5197	−0.4079	1.447	0.2708
	MDC	−0.7171	−2.992	1.558	0.5353
	MIP-1α	−0.7171	−2.992	1.558	0.5353
	MIP-1β	0.08906	−0.4774	0.6555	0.7570
	TARC	−0.1315	−0.3080	0.04493	0.1433
Cytokine	IL-12/23 p40	0.02485	−0.4662	0.5159	0.9207
	IL-15	0.1547	−0.03270	0.3421	0.1052
	IL-16	1.367	−3.425	6.159	0.5747
	IL-17A	0.6550	−1.319	2.629	0.5139
	IL-1α	87.51	12.94	162.1	0.0216
	IL-5	−0.003209	−0.2306	0.2241	0.9778
	IL-7	−0.004470	−0.1665	0.1576	0.9567
	LTA	0.004860	−0.1218	0.1315	0.9398
	VEGF	19.25	−2.023	40.52	0.0759
Proinflammatory	IFNγ	3.607	−3.413	10.63	0.3124
	IL-10	1.296	−0.04960	2.641	0.0590
	IL-13	0.1148	−0.5554	0.7851	0.7360
	IL-1β	3.015	0.2192	5.810	0.0347
	IL-2	0.6627	−0.3325	1.658	0.1908
	IL-4	0.06967	−0.1617	0.3010	0.5535
	IL-6	1.415	−0.2765	3.106	0.1007
	IL-8	40.28	4.368	76.19	0.0281
	TNF	−0.04665	−0.3570	0.2637	0.7674
Vascular Injury	CRP	1134	411.7	1857	0.0022
	SAA	1.357	−82.79	85.79	0.9747
	sICAM-1	7.169	−5.786	20.12	0.2767
	sVCAM-1	0.4134	−5.982	6.809	0.8988

Gray shading indicates significant (p<0.05) association with PD status parameter by multivariate GLM, multiple imputation = 5