Figure 5. Serum CXCL12 (SDF-1) levels are increased in animals with endometriosis lesions.
A: Serum CXCL12 expression in endometriosis induced (EMS) and endometriosis induced and ovariectomy (EMS+OVX) mice at one and two weeks after induction. Compared to the sham surgery group, high serum CXCL12 levels were detected in all four experimental groups (P < 0.01). B: Similar to the murine model, human serum CXCL12 levels were increased in women with endometriosis. C: Western blotting analysis of ectopic lesions in EMS and EMS+OVX mice. Compared to the sham group higher levels of CXCL12 was detected in endometriosis; a indicates sham vs EMS P < 0.01; b indicates sham vs EMX+OVX P < 0.01.