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. Author manuscript; available in PMC: 2019 Jun 1.
Published in final edited form as: J Intern Med. 2018 Mar 24;283(6):568–577. doi: 10.1111/joim.12744

Figure 3.

Figure 3

Immunophenotypic features of the left colon of ipilimumab-associated colitis (Ipi-AC), ulcerative colitis (UC), and normal controls (Ctrl). The density of cells that stained positive for CD4, CD8, CD20, CD138, and FOXP3 was assessed using immunohistochemistry. There was no difference in the density of (A) CD4, (B) CD8, or (C) CD138-positive cells between any of the groups (p>0.05). (D) The Ipi-AC group had less CD20-positive cells in the left colon compared to UC (p=0.022). There was no difference in the density of CD20-positive cells between the Ipi-AC and Ctrl groups (p>0.05). (E) The total density of FOXP3-positive cells was similar among all groups (p>0.05). (F) There was no difference in the FOXP3/CD4 ratio between Ipi-AC and UC (p>0.05), but the Ipi-AC group had an increased FOXP3/CD4 ratio compared to Ctrls (p=0.0008). Unpaired Student’s t-test was used for all analyses. * p< 0.05, ** p<0.01, *** p<0.001