Table 1.
Demographic, clinical characteristics, endoscopic findings, and histopathologic findings of ipilimumab-associated colitis (Ipi-AC, n=22), ulcerative colitis (UC, n=12), and normal controls (Ctrl, n=5). The presence of mucosal ulcerations, cryptitis, crypt abscesses, basal plasmacytosis, and crypt distortion is depicted as the number and percentage of patients with the histopathologic feature in at least one biopsy site. Crypt distortion was further subclassified as mild, moderate or severe depending on the severity of crypt irregularities. Cryptitis, crypt abscesses, and apoptotic bodies were quantified per 10 high power field (HPF) in the left colon.
| Ipi-AC (n=22) | UC (n=12) | Ctrl (n=5) | ||
|---|---|---|---|---|
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| Age (years) | 62 ± 11.7 | 42 ± 17.8* | 49 ± 16.6# | |
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| Sex (% female) | 7 (32%) | 8 (67%) | 3 (60%) | |
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| Most common clinical symptom | Watery diarrhea (n=21, 95%) | Hematochezia (n=9, 75%) | Watery diarrhea (100%) | |
|
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| Most common endoscopic findings | Edematous and erythematous mucosa (n=8, 36%) | Erythematous, friable and ulcerated mucosa (n=9, 75%) | Normal (n=5, 100%) | |
|
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| Sites biopsied [N (%)] | ||||
| left colon | 22 (100%) | 12 (100%) | 5 (100%) | |
| Right colon | 11 (50%) | 7 (58%) | 2 (40%) | |
| Ileum | 6 (27%) | 3 (25%) | 3 (60%) | |
|
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| Presence of mucosal ulceration [N (%)] | 10 (45%) | 7 (58%) | 0 (0%)# | |
|
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| Cryptitis | ||||
| Presence [N (%)] | 16 (73%) | 10 (83%) | 0 (0%)## | |
| Quantitative (#/10 HPF) | 3.6 ± 5.3 | 11.6 ± 6.3*** | 0 ± 0## | |
|
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| Crypt Abscesses | ||||
| Presence [N (%)] | 7 (32%) | 8 (67%)* | 0 (0%) | |
| Quantitative (#/10 HPF) | 1.8 ± 3.8 | 1.8 ± 2.4 | 0 ± 0 | |
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| Presence of basal plasmacytosis [N (%)] | 3 (14%) | 11 (92%)*** | 0 (0%) | |
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| Crypt distortion [N (%)] | ||||
| Presence (any) | 5 (23%) | 9 (75%)** | 0 (0%) | |
| Mild | 4 (18%) | 3 (25%) | 0 (0%) | |
| Moderate | 1 (5%) | 4 (33%) | 0 (0%) | |
| Severe | 0 (0%) | 2 (17%) | 0 (0%) | |
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| Apoptotic Bodies (per 10 HPF) | 16.6 ± 15.6 | 7.3 ± 4.7* | 0.8 ± 0.4### | |
Data are depicted as mean ± SD. Comparisons were made between Ipi-AC and UC as well as Ipi-AC and Ctrls using chi-squared analysis for categorical variables and the Student’s t-test for continuous variables.
For Ipi-AC vs. UC: * p<0.05, ** p<0.01, *** p<0.001.
For Ipi-AC vs. Ctrl: # p<0.05, # p<0.01, ## p<0.001