Table 1. Patient characteristics at diagnosis and treatments.

P-values are for comparisons of non-CK vs CK groups. Percentages only refer to patients for whom data for a given variable is available, missing data not included.

Characteristic	All patients	Complex karyotype	Non-complex	p
	(n=274)	(n=53)	(n=221)
Median age (range)	63 (32-83)	63 (43-81)	63(32-83)	0.57
Male sex, n(%)	189 (69)	34 (64)	155 (70)	0.4
MIPI Group, n(%)				<0.01
Low	49 (29)	4 (12)	45 (33)
Intermediate	67 (40)	11 (33)	56 (41)
High	52 (31)	18 (55)	34 (25)
Ki67 expression, n(%)				0.19
Ki67 > 30%	59 (47)	11 (58)	48 (45)
Ki67 ≤ 30%	66 (53)	8 (42)	58 (55)
ECOG PS, n(%)				0.05
0 or 1	211 (92)	38 (84)	173 (94)
2, 3 or 4	19 (8)	7 (16)	12 (6)
Stage				0.15
I/II	9 (3)	0 (0)	9 (4)
III/IV	256 (97)	52 (100)	204 (96)
Bone marrow involvement				<0.01
Yes	220 (83)	47 (96)	173 (80)
No	45 (17)	2(4)	43 (20)
GI involvement				0.37
Yes	33 (18)	2 (11)	31 (20)
No	150 (82)	17 (89)	188 (81)
Splenomegaly				<0.01
Yes	144 (57)	41 (80)	103 (52)
No	107 (42)	10 (20)	97 (49)
Elevated LDH				<0.01
Yes	91 (41)	28 (60)	63 (36)
No	132 (59)	19 (40)	113 (64)
WBC > 10,000				<0.01
Yes	87(35)	26 (53)	61 (31)
No	159 (65)	23 (47)	136 (69)
Nodal mass > 10cm				0.78
Yes	12 (5)	2 (4)	10 (5)
No	236 (95)	47 (96)	189 (95)
Constitutional symptoms				<0.01
Yes	86(33)	24 (50)	62 (29)
No	176 (67)	24 (50)	152 (71)
High intensity induction regimen				0.34
Yes	117 (48)	26 (54)	91 (46)
No	127 (52)	22 (46)	105 (54)
ASCT in CR1				0.88
Yes	111 (49)	20 (50)	91 (49)
No	116 (51)	20 (50)	96 (51)
Year of diagnosis				<0.01
2006 and earlier	44 (16)	10 (19)	34 (15)
2007-2009	64 (23)	8 (15)	56 (25)
2010-2012	95 (35)	28 (53)	67 (30)
2013-2015	71 (26)	7 (13)	64 (29)