Table 3.
Factors Associated with Discordant Perceptions of Risk for Infertility Among Survivors Exposed to Gonadotoxic Therapy
| Factors | Categories | Adjusted Odds Ratio | p-value |
|---|---|---|---|
| Age at primary cancer diagnosis | <=4 yrs | 1.00 (ref. level) | -- |
| 5–9 yrs | 0.91 (0.53–1.57) | 0.73 | |
| 10–14 yrs | 0.80 (0.47–1.37) | 0.42 | |
| 15–21 yrs | 1.20 (0.70–2.07) | 0.51 | |
|
| |||
| Race /Ethnicity | White non-Hispanic | 1.00 (ref. level) | -- |
| Other | 2.28 (1.10–4.75) | 0.03 | |
|
| |||
| History of fathering children | Yes | 4.14 (2.74–6.24) | <0.001 |
| No | 1.00 (ref. level) | -- | |
|
| |||
| Education achievement | Did not attend college | 1.94 (0.99–3.79) | 0.05 |
| Some college | 1.71 (0.95–3.08) | 0.08 | |
| College graduate | 1.37 (0.82–2.28) | 0.23 | |
| Post graduate level | 1.00 (ref. level) | -- | |
|
| |||
| Personal income | Less than $20,000 | 3.23 (1.53–6.82) | <0.01 |
| $20,000 – $39,999 | 2.61 (1.34–5.09) | <0.01 | |
| $40,000 – $59,999 | 2.62 (1.39–4.92) | <0.01 | |
| $60,000 – $79,999 | 2.00 (1.03–3.87) | 0.04 | |
| $80,000 – $99,999 | 0.89 (0.37–2.17) | 0.80 | |
| Over $100,000 | 1.00 (ref. level) | -- | |
|
| |||
| Most recent participation in long-term follow-up care | Less than 3 years | 1.00 (ref. level) | -- |
| 3 or more years | 0.85 (0.57–1.28) | 0.45 | |
| Never | 3.07 (1.57–5.99) | <0.01 | |
|
| |||
| History of testosterone treatment | Yes | 0.41 (0.17–0.98) | <0.05 |
| No | 1.00 (ref. level) | -- | |
|
| |||
| History of erectile dysfunction treatment | Yes | 0.32 (0.13–0.80) | 0.01 |
| No | 1.00 (ref. level) | -- | |
|
| |||
| >40 Gy cranial radiation† | Yes | 2.88 (1.41–5.88) | <0.01 |
| No | 1.00 (ref. level) | -- | |
|
| |||
| Pelvic or testicular radiation† | Yes | 0.33 (0.19–0.59) | <0.001 |
| No | 1.00 (ref. level) | -- | |
|
| |||
| Total body irradiation (TBI) | Yes | 0.36 (0.04–3.52) | 0.38 |
| No | 1.00 (ref. level) | -- | |
|
| |||
| Alkylator agent exposure | Yes | 0.32 (0.16–0.64) | <0.01 |
| No | 1.00 (ref. level) | -- | |
|
| |||
| Orchiectomy | Yes | 0.10 (0.01–1.00) | <0.05 |
| No | 1.00 (ref. level) | -- | |
†
does not include TBI