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. Author manuscript; available in PMC: 2019 Jun 1.
Published in final edited form as: Clin Exp Allergy. 2018 Apr 15;48(6):691–702. doi: 10.1111/cea.13123

Fig. 5. Heat-inactivation of A. alternata blunts the lethal response to influenza virus.

Fig. 5

A. Filtrate of A. alternata heated to 95°C for 10 minutes retains little to no residual protease activity using casein as a substrate; ***p < 0.001. B. Heat-inactivated filtrate of A. alternata (hi-Aa) administered to upper airways as in Fig. 1A promotes eosinophil recruitment to the upper airways as does the active filtrate (Aa), n = 5 mice per group; ns, no significant difference, Mann-Whitney U-test. C. Survival of wild-type mice challenged with A. alternata (Aa), hi-Aa or diluent control as in Fig. 4A followed by Inf A (150 TCID50 units in 5 μL); n = 9 – 10 mice per group, *p = 0.05, **p < 0.005, Log-rank.