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. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: Pharmacol Ther. 2018 Apr 3;187:180–194. doi: 10.1016/j.pharmthera.2018.03.009

Fig. 2. Organ-specific EVs are circulated in the blood after drug-induced organ injury.

Fig. 2

Wild-type male BALB/c mice (6 weeks old) were treated with PBS, MPTP (30 mg/kg), APAP (200 mg/kg), CIS (10 mg/kg), or CPP (200 mg/kg) for 24 h (n = 10/group). (A) Western blot analysis of liver-specific proteins (ALB, HP, and FGB), kidney-specific proteins (Kim-1 and NGAL), a heart-specific protein (cTnI), and a brain-specific protein (SB) in circulating EVs isolated from plasma of each group. (B) Organ-specific proteins in EVs could be used as potential biomarkers for drug-induced tissue injury.