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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Nat Med. 2018 May 21;24(6):847–856. doi: 10.1038/s41591-018-0025-7

Fig. 5. Monocyte markers of protection identified in the present study are associated with the number of SIV challenges to infection in previous studies with ALVAC–SIV or gp96 SIV prime.

Fig. 5

a, Heatmaps showing the expression of the 88 monocytes markers of protection after DNA (n = 12 animals), ALVAC (n = 24 animals) or gp96 prime inoculation (n = 12 animals). All transcriptomic data collected after immunization were used to perform this analysis (DNA: 24 h and 1 or 2 weeks after immunization; ALVAC: 24 h and 1 week after immunization; gp96: 1, 7 and 17 weeks after immunization). Samples were ordered from left to right by increasing mean expression of the 88 monocytes markers. A Pearson correlation and t-test were performed to statistically evaluate the association between the markers of protection and the number of SIV challenges to infection. NA, value not available. b,c, A similar analysis (as in a) for inflammasome (b) and TH2-associated (c) genes. d, The expression of the 88 monocytes markers of protection, the NLRP3 inflammasome and TH2-associated genes are correlated with each other. A Student’s t-test was used to test the significance of the correlation. Only correlations associated with P < 0.05 are presented in the network.