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. 2018 May 10;102(6):1031–1047. doi: 10.1016/j.ajhg.2018.03.023

Figure 2.

Figure 2

Predicted Risk Genes and Enhancers of ASD

(A) GeneMania network analysis of the four “novel ASD genes.” Red circles represent novel ASD genes while gray circles represent known ones. Two genes are connected if their co-expression across multiple tissues reaches a threshold. Only connections between the two gene sets are shown.

(B) Distribution of the number of enhancers with recurrent (two or more) de novo SNVs from 10,000 simulations. The vertical red arrow marks the observed number of enhancers with recurrent de novo SNVs.

(C) A distal enhancer (marked by a star) of ZMIZ1 with recurrent SNVs. Grey curves represent possible interactions between enhancers and promoters (correlated activities across multiple tissues). Note that the region contains two additional DNMs in other sequences.