Table 1.

Mutation Frequency (the Number of Mutations per Subject) and the Relative Risks of Different Types of De Novo Mutations

Mutation Class	Mutation Frequency	Relative Mutational Exposure (%)	Relative Risk	Variance of ASD Liability Explained (100%)
Mis3	0.0175	12.5	4.70	0.83
Loss-of-function	0.00405	2.90	20.0	1.08
H3K27ac SNV (Gerp < = 2)	0.0839	59.9	1.54	0.24
H3K27ac SNV (Gerp > 2)	0.0164	11.7	3.42	0.46
Splicing SNV	0.0183	13.1	3.22	0.46