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. 2018 Jun 7;8:8701. doi: 10.1038/s41598-018-27025-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Hyperacetylation suppresses growth of MDA-MB-231 cells implanted in female nude mice. (A–D) Effect of oral administration of 20 mg/(kg·day) ASA plus subcutaneous injection of 0.5 mg/kg TSA three times weekly on total body weight (A), body weight in the absence of tumors (B), tumor volume, (C) and wet-tumor weight (D). Data reflect the mean (n = 6–7 mice/group, with tumor cells orthotopically injected into the mammary fat pad of each mouse). *P < 0.05 versus control mice according to one-way ANOVA, followed by Bonferroni’s test. (E) Representative micro-CT of xenografts treated with 20 mg/(kg·day) + 0.5 mg/kg TSA, TSA alone or SA.