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. 2018 Jun 7;8:8702. doi: 10.1038/s41598-018-27027-7

Figure 3.

Figure 3

Biological pathways and functional networks modulated by ZIKV in hSeC at 48 hpi. (A) Top IPA Canonical Pathways across entire dataset at 48 hpi. Pathways order by most significant (Fisher’s exact test right-tailed). Antiviral and innate immune response pathways were predominantly upregulated. Stacked bars represent percentage of genes modulated and/or IPA predicted out of total (in bold, right) in pathway. (B) Significant DEGs (p < 0.05; determined by limma in Bioconductor) of select antiviral pathways at 48 hpi meeting log2 FC cutoff of >|1.5|. (C) Top scoring IPA functional network at 48 hpi: Infectious Diseases, Cell Signaling, Antimicrobial Response network. Solid line between nodes represents direct interaction and dashed line represents indirect interaction. Nodes ranked by log2 FC. Node shapes represent functional classes of gene products. Vertical diamond shaped nodes represent enzymes; horizontal diamond peptidases; trapezoid transporters; triangle kinases; horizontal oval transcription regulators; vertical oval transmembrane receptors; rectangle growth factors; circle proteins. Node color indicates level of expression. Red is upregulated, and blue is downregulated. IPA functional network cutoff criteria for DEGs was log2 FC >|1.5| (p < 0.05).