Table 1.
Top 30 upstream regulators with predicted activity at 12 hpi by significance (Fisher’s exact test right-tailed).
| Upstream Regulator | Expr Log Ratio | Molecule Type | Predicted Activation State | Activation z-score | p-value of overlap |
|---|---|---|---|---|---|
| CDKN1A | 0.379 | kinase | Activated | 2.185 | 1.13E-25 |
| TP53 | −0.66 | transcription regulator | Activated | 2.877 | 2.96E-18 |
| HGF | growth factor | Inhibited | −2.281 | 1.10E-16 | |
| PTGER2 | g-protein coupled receptor | Inhibited | −2.013 | 4.46E-16 | |
| NUPR1 | 0.941 | transcription regulator | Activated | 5.292 | 1.76E-15 |
| FOXM1 | −1.99 | transcription regulator | Inhibited | −2.915 | 3.02E-15 |
| CSF2 | 1.284 | cytokine | Inhibited | −2.295 | 1.01E-14 |
| E2F3 | 0.212 | transcription regulator | Inhibited | −2.515 | 1.93E-13 |
| EP400 | −0.265 | other | Inhibited | −2.621 | 6.90E-12 |
| IL6 | 2.707 | cytokine | Activated | 2.248 | 3.70E-11 |
| RB1 | −0.298 | transcription regulator | Activated | 2.595 | 4.24E-11 |
| mir-21 | microrna | Activated | 3.614 | 5.25E-11 | |
| RABL6 | 0.015 | other | Inhibited | −3.162 | 1.50E-10 |
| F10 | peptidase | Activated | 2.041 | 1.75E-10 | |
| EDN1 | 1.025 | cytokine | Activated | 2.515 | 1.14E-09 |
| TBX2 | −0.171 | transcription regulator | Inhibited | −3 | 1.39E-08 |
| F2 | peptidase | Activated | 2.614 | 4.25E-08 | |
| P38 MAPK | group | Activated | 2.342 | 6.92E-08 | |
| AGER | 0.824 | transmembrane receptor | Activated | 2.495 | 1.07E-07 |
| F2R | 0.115 | g-protein coupled receptor | Activated | 2.454 | 1.10E-07 |
| E2F1 | −1.381 | transcription regulator | Inhibited | −2.007 | 1.35E-07 |
| HDAC2 | −0.761 | transcription regulator | Activated | 2.449 | 1.40E-07 |
| S1PR2 | 0.168 | g-protein coupled receptor | Activated | 2.197 | 1.54E-07 |
| IL17A | cytokine | Activated | 2.59 | 1.58E-07 | |
| TGFB1 | 0.052 | growth factor | Activated | 3.567 | 1.76E-07 |
| OSM | cytokine | Activated | 2.708 | 5.28E-07 | |
| F2RL1 | −0.405 | g-protein coupled receptor | Activated | 2.586 | 6.58E-07 |
| LEP | growth factor | Activated | 2.476 | 6.97E-07 | |
| MITF | transcription regulator | Inhibited | −3.464 | 7.49E-07 | |
| HDAC1 | −0.842 | transcription regulator | Activated | 2.135 | 8.55E-07 |