Table 3.
Top 30 upstream regulators with predicted activity at 72 hpi by significance (Fisher’s exact test right-tailed).
| Upstream Regulator | Expr Log Ratio | Molecule Type | Predicted Activation State | Activation z-score | p-value of overlap |
|---|---|---|---|---|---|
| IFNA2 | cytokine | Activated | 6.446 | 3.00E-48 | |
| IFNL1 | cytokine | Activated | 5.565 | 4.68E-47 | |
| Interferon alpha | group | Activated | 5.87 | 4.54E-46 | |
| IRF7 | 0.998 | transcription regulator | Activated | 5.698 | 2.78E-37 |
| PRL | cytokine | Activated | 4.645 | 1.92E-36 | |
| MAPK1 | −0.646 | kinase | Inhibited | −4.861 | 2.10E-36 |
| IFNG | cytokine | Activated | 6.69 | 9.55E-35 | |
| CNOT7 | −0.408 | transcription regulator | Inhibited | −2.621 | 1.21E-34 |
| STAT1 | 2.91 | transcription regulator | Activated | 5.339 | 5.97E-34 |
| EIF2AK2 | 1.042 | kinase | Activated | 4.557 | 9.25E-34 |
| NKX2-3 | transcription regulator | Inhibited | −4.536 | 4.12E-33 | |
| IRF1 | 2.538 | transcription regulator | Activated | 4.786 | 2.74E-30 |
| IRF3 | 0.322 | transcription regulator | Activated | 4.998 | 3.03E-26 |
| IRF5 | transcription regulator | Activated | 4.349 | 1.73E-25 | |
| TRIM24 | 0.106 | transcription regulator | Inhibited | −4.623 | 1.79E-25 |
| IFN Beta | group | Activated | 4.674 | 5.61E-25 | |
| Ifnar | group | Activated | 4.518 | 7.21E-25 | |
| IL1RN | cytokine | Inhibited | −4.123 | 2.97E-24 | |
| Ifn | group | Activated | 4.146 | 2.28E-23 | |
| IFNB1 | cytokine | Activated | 4.47 | 1.01E-20 | |
| IFNA1/IFNA13 | 0.008 | cytokine | Activated | 3.91 | 1.32E-20 |
| MAVS | 0.446 | other | Activated | 3.971 | 2.51E-20 |
| TLR7 | transmembrane receptor | Activated | 4.342 | 7.76E-20 | |
| STAT2 | 1.915 | transcription regulator | Activated | 2.392 | 1.33E-19 |
| TGM2 | 0.182 | enzyme | Activated | 4.757 | 1.52E-19 |
| TLR3 | transmembrane receptor | Activated | 3.88 | 1.66E-19 | |
| IFNAR1 | 0.444 | transmembrane receptor | Activated | 2.769 | 1.30E-17 |
| ACKR2 | g-protein coupled receptor | Inhibited | −3.464 | 1.66E-16 | |
| TLR9 | transmembrane receptor | Activated | 4.358 | 5.52E-15 | |
| TNF | cytokine | Activated | 5.929 | 4.85E-14 |