Table 1.
Ski and SnoN levels in cancer
| Cancer types | Cofactor | Expression | Mechanism | References |
|---|---|---|---|---|
| Acute myeloid leukemia | Ski | Upregulated | Loss-of-Ski regulation by miR-29a | 104,282 |
| Breast cancer | SnoN | Upregulated | N.D. | 255 |
| Cervical | Ski | Upregulated | N.D. | 85,271 |
| Chronic Myelogenus Leukemia | Ski | Upregulated | N.D. | 258 |
| Colorectal | Ski | Downregulated | Partial or complete allelic loss | 256,262 |
| Upregulated | Ski gene amplification | |||
| SnoN | Downregulated | Partial or complete allelic loss | 256,275 | |
| Upregulated | Skil gene amplification | |||
| Esophageal | Ski | Upregulated | N.D. | 257,274 |
| SnoN | Upregulated | Stability of SnoN protein | 254,260,274 | |
| Skil gene amplification | ||||
| Gastrointestinal | Ski/SnoN | Upregulated | N.D. | 265,267,269,270 |
| Hemangioma | Ski | Upregulated | N.D. | 266 |
| Hepatocarcinoma | SnoN/Ski | Upregulated | N.D. | 172 |
| Lymphoma | SnoN | Downregulated | sno-heterozygous mice | 178 |
| Lung cancer | Ski | Downregulated | Ski gene methylation | 101 |
| Melanoma | Ski/SnoN | Upregulated | N.D. | 162,163,253,259,263,264 |
| Nasopharyngeal | SnoN | Upregulated | Skil gene amplification | 277 |
| Ovarian | SnoN | Upregulated | Skil gene amplification | 81,279 |
| Pancreatic | Ski/SnoN | Upregulated | N.D. | 261,268,272,281 |
N.D. Not Demonstrated