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. 2018 May 9;275(7):1837–1843. doi: 10.1007/s00405-018-4997-1

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — a Typical nuclear blue in situ hybridization reaction in HPV-associated squamous cell carcinoma (Original magnification 1:400). b Squamous cell carcinoma without in situ hybridization signal, representing HPV negative tumour (Original magnification 1:400). c HPV-associated squamous cell carcinoma with strong p16 positivity (Original magnification 1:400). d P16 negative squamous cell carcinoma (Original magnification 1:400)