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. 2018 Jun 1;9:555. doi: 10.3389/fphys.2018.00555

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Copyright © 2018 Mertens, Hanmandlu, Tu, Phan, Collum, Chen, Weng, Davies, Liu, Eltzschig, Jyothula, Rajagopal, Xia, Guha, Bruckner, Blackburn, Guignabert and Karmouty-Quintana.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dual immunohistochemistry (IHC) from representative vessels from PBS or BLM exposed Tagln^Cre and Adora2b^f/f−Tagln^Cre mice stained for (A) alpha smooth muscle actin (αSMA, blue) and nuclear P-STAT3 (brown signals); (B) represent fibrotic areas rich in myofibroblasts (αSMA positive) where PSTAT is present; (C) αSMA, blue and transglutaminase (TGM2, red signals) (D) represents fibrotic areas rich in myofibroblasts (αSMA positive) where TGM2 is also present. Scale bar represents 200 μm. Arrow heads point and p-STAT3 or TGM2 positive cells in the vessel wall (αSMA positive).