Figure 8.

Response of primary human pulmonary artery smooth muscle cells (PASMCs) to activation of ADORA2B). Expression levels of HAS2 (A,B); IL-6 (C,D); and TGM2 (E,F) under normoxia (A–C) or under hypoxia (2%O₂, D–F) of human PASMC exposed to DMSO (white bars); the ADORA2B antagonist: GS-6201 (light gray bars); the ADORA2B agonist: BAY60-6583 (black bars) or under the presence of both GS-6201 and BAY60-6583 (dark gray bars). ^*P < 0.05 refers to comparisons between DMSO and BAY60-6583 treatment groups and ^#P < 0.05, are for comparisons between BAY60-6583 and BAY60-6583 + GS-6201 treatment groups. N = 5 for all groups.