Table 4.
Association of polymorphisms with serum vitamin D metabolite levels under three genetic models (N = 1727).
| SNP | M/m | Median levels (ng/mL) |
p-value* |
|||||
|---|---|---|---|---|---|---|---|---|
| Additive | Dominant | Recessive | ||||||
| 1. rs12785878 (DHCR7/NADSYN1) |
G/T | Total serum 25(OH)D | 23.80 | 24.37 | 24.54 | 0.001 | 0.001 | 0.077 |
| Non-C3-epimers | 22.43 | 22.94 | 22.82 | 0.002 | 0.002 | 0.155 | ||
| C3-epimers | 1.25 | 1.34 | 1.50 | 1.66 × 10−7 | 2.00 × 10−6 | 3.89 × 10−4 | ||
| 2. rs2060793 (CYP2R1) |
G/A | Total serum 25(OH)D | 23.40 | 24.37 | 25.61 | 7.60 × 10−8 | 5.48 × 10−7 | 3.66 × 10−4 |
| Non-C3-epimers | 22.06 | 22.94 | 24.45 | 2.46 × 10−8 | 1.97 × 10−7 | 2.31 × 10−4 | ||
| C3-epimers | 1.29 | 1.33 | 1.37 | 0.093 | 0.123 | 0.252 | ||
| 3. rs2282679 (GC) |
T/G | Total serum 25(OH)D | 24.92 | 23.24 | 19.78 | 1.54 × 10−19 | 5.80 × 10−15 | 6.26 × 10−12 |
| Non-C3-epimers | 23.57 | 21.85 | 18.48 | 7.30 × 10−20 | 3.16 × 10−15 | 4.46 × 10−12 | ||
| C3-epimers | 1.36 | 1.28 | 1.10 | 1.10 × 10−5 | 1.43 × 10−4 | 0.001 | ||
Abbreviations: M/m Major allele/minor allele.
Total serum 25(OH)D levels, non-C3-epimer levels and C3-epimer levels are presented as median levels (ng/mL).
All vitamin D metabolite levels used a natural logarithmic (Ln) transformation for simple linear regression analysis.
*
Simple linear regression provided p-values; p < 0.001 was considered statistically significant. Bold font indicates the additive model was a better fit for models.