Table 3.
Patterns of Staining of HSP70, Glutamine Synthetase and Glypican3 in HCC.
Antibody | Pattern of staining | Interpretation (positive/negative) |
---|---|---|
Glutamine synthetase (GS) | Diffuse strong cytoplasmic positivity unrelated to vascular structures/septae | Positive (19/35) |
Patchy strong positivity along the septae | Negative (11/35) | |
HSP70 | Diffuse strong cytoplasmic with nuclear positivity | Positive (17/35) |
Isolated cytoplasmic positivity | Negative (4/35) | |
Glypican3 (GPC3) | Cytoplasmic positivity/strong membranous positivity in >10% of cells | Positive (10/35) |
Occasional cells positive/weak cytoplasmic staining | Negative (8/35) |