Figure 5.

Effects of Secreted Hutat2:Fc on the Distributions of T Cell Subsets and Exhaustion Status after Exposure to HIV-1_Ba-L

(A) Representative FACS plots of the distributions of CD4⁺ and CD8⁺ T cell subsets after HIV-1_Ba-L infection, with or without KI-M-Hutat2. Commercial anti-Tat antibodies were used as a positive control. (B) Comparison of CD4⁺ and CD8⁺ T distributions following treatment with or without each type of conditioned media (n = 6). (C) Expression of CD38 and HLA-DR in CD4⁺ and CD8⁺ T cells treated with or without each type of conditioned media (n = 6). (D) Expression of PD-1, PD-L1, and CTLA-4 in CD4⁺ and CD8⁺ T cells treated with or without each type of conditioned media (n = 6). Wilcoxon matched-pairs signed-ranks tests were used to statistically compare the data shown in (B)–(D); *p < 0.05. The results are presented as the medians from independent experiments.