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. 2018 May 29;9:183. doi: 10.3389/fgene.2018.00183

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Copyright © 2018 Sanati, Iancu, Wu, Jacobs and McWeeney.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Network structure of 18 DW hub genes showed striking expression connectivity measure differences between HNSCC progressor (left) and non-progressor (right) conditions. These genes were identified as differentially wired hub nodes in the turquoise module [kME > 0.8 and enriched in changed edges (p < 0.01; Binomial)]. Visually, wiring width demonstrates correlation magnitude strength. Weights are correlations > 0.6 to capture mid/low strength connectivity in the non-progressor condition. The size of each gene's node indicates overall connectivity strength.