Figure 4.

Docking of C-reactive protein (CRP) to leptin–leptin receptor complex. Leptin (PDB Id 1AX8) –leptin receptor (CRH2–FNIII) complex was prepared, the complex was energy minimized, prepared for further docking as described in Section “Materials and Methods” and docked with CRP (PDB Id 1GNH). Protein–protein docking was done as described in Figure 1. The image of the pose with the best Z-rank score in the largest cluster is shown. (A) Leptin (pink) was docked (site specific) to modeled leptin receptor [CRH2 (deep blue)–Fn III (light blue)], CRP monomer (green). (B) Enlarged image of docked amino acid skeleton.