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. Author manuscript; available in PMC: 2018 Dec 4.
Published in final edited form as: Nat Med. 2018 Jun 4;24(6):721–723. doi: 10.1038/s41591-018-0056-0

Figure 2. Therapeutic and prophylactic efficacy of B10 in rhesus monkeys.

Figure 2

Figure 2

Figure 2

Rhesus monkeys (N=4/group) received 10 mg/kg B10 or the isotype matched sham control antibody PGT121 by the i.v. route on day −1 or day +2. All animals were challenged on day 0 by the s.c route with 106 VP (103 PFU) ZIKV-BR. Viral loads are shown in (a) plasma, (b) cerebrospinal fluid (CSF), and (c) lymph nodes (LN). Viral loads were determined on days 0, 1, 2, 3, 4, 5, and 7 for the plasma samples and on days 0, 3, 7, 14, and 35 for the other samples. Assay sensitivity 100 copies/ml or 1×106 cells. Arrows designate the day +2 infusions.