Figure 7.

MiR-146b-5p is required for NK cell-induced inhibition of oxaliplatin-resistant colorectal cancer cell lines in vitro. Oxaliplatin-resistant (OR)-DLD1 and OR-RKO cells stably transduced with control miR inhibitor (control) or miR-146b-5p inhibitor (anti-miR) in the absence (NK cell -) or presence (NK cell +) of co-cultured natural killer cells, respectively, were subjected to (A) viability, (B) proliferation, (C) wound healing and (D) transwell invasion assays. Data are presented as mean ± SD from at least three independent experiments. **P<0.01, *P<0.05, NK cell +/control vs both NK cell -/control and NK cell +/anti-miR. ns not significant, NK cell -/control vs NK cell +/anti-miR.