Figure 8.

MiR-146b-5p is required for NK cell-induced inhibition of oxaliplatin-resistant colorectal cancer cell lines in vivo. A and B. Oxaliplatin-resistant (OR)-DLD1 and OR-RKO cells stably transduced with control miR inhibitor (control) or miR-146b-5p inhibitor (anti-miR) were injected into mice (n=8 each group), without (NK cell -) or with co-injection of natural killer cells (NK cell +), respectively, followed by growth curve evaluation on day 7, 14 and 21 after injection. C. At the end of day 21, xenograft tumors from all mice were extracted and weighed. Data are presented as mean ± SD, n=8 each group. **P<0.01, *P<0.05, NK cell +/control vs both NK cell -/control and NK cell +/anti-miR. ns not significant, NK cell -/control vs NK cell +/anti-miR.