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. 2018 Jun 1;10:164. doi: 10.3389/fnagi.2018.00164

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Copyright © 2018 Huang, Liang, Chen, Xu, Chai and Xing.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Fluoxetine enhances the non-amyloidogenic pathway in 3×Tg-AD mice brain. (A) The western blot analysis was used to examine the expression levels of APP and APP cleavage enzymes, including APP, CTFβ, CTFα, ADAM10, BACE1, and PS1. (B) Levels of APP cleavage fragments, including sAPPα, sAPPβ, C83, and C99 generation, in the brain of three groups were assessed and quantified by immunoblotting. WT, wild-type mice; Tg: 3×Tg-AD mice; Tg + FLX: fluoxetine treated 3×Tg-AD mice. All data were shown as mean ± SD, n = 12 animals/group. ^∗p < 0.05, ^∗∗p < 0.01.