Table 3.
Top three significant modules selected from the protein-protein interaction network
| Module | Name | Count | P value | Genes |
|---|---|---|---|---|
| Module 1 | Neuroactive ligand-receptor interaction | 5 | 1.22E-05 | EDNRB, AGTR1, CYSLTR2, ADRA1A, LPAR1 |
| cGMP-PKG signaling pathway | 4 | 1.31E-04 | EDNRB, AGTR1, ADRA1A, PIK3R1 | |
| Calcium signaling pathway | 4 | 1.65E-04 | EDNRB, AGTR1, CYSLTR2, ADRA1A | |
| Pathways in cancer | 4 | 1.68E-03 | EDNRB, AGTR1, LPAR1, PIK3R1 | |
| Adrenergic signaling in cardiomyocytes | 3 | 4.25E-03 | AGTR1, ADRA1A, PIK3R1 | |
| Module 2 | p53 signaling pathway | 2 | 2.8E-02 | CCNB2, RRM2 |
| Module 3 | Glutathione metabolism | 7 | 8.31E-13 | GSTM1, GSTM2, GSTM3, GSTM4, GPX3, GSTM5, GSTP1 |
| Drug metabolism-cytochrome P450 | 7 | 5.04E-12 | GSTM1, GSTM2, CYP3A5, GSTM3, GSTM4, GSTM5, GSTP1 | |
| Metabolism of xenobiotics by cytochrome P450 | 7 | 8.52E-12 | GSTM1, GSTM2, CYP3A5, GSTM3, GSTM4, GSTM5, GSTP1 | |
| Chemical carcinogenesis | 7 | 1.38E-11 | GSTM1, GSTM2, CYP3A5, GSTM3, GSTM4, GSTM5, GSTP1 |