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The role of lincRNA-p21 in renal function and pathological changes of DN in db/db mice. The level of clinical biochemical indexes were up-regulated remarkably in db/db mice, which was significantly improved by si-lincRNA-p21, including blood glucose, BUN, creatinine and urine albumin (A-D; #P<0.05, *P<0.05). HE and PAS staining showed the degree of pathological changes was lightened when db/db mice received si-lincRNA-p21 treatment (E).
