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MiR-18b directly targets with 3’-UTR of CTGF. The 3’-UTR binding sites can be seen in (A). Luciferase reporter assay showed transfection of miR-18b could significantly restrict the relative luciferase activity in cells (B, *P<0.05). Overexpression of miR-18b obviously inhibited CTGF expression in cells at the mRNA and protein levels. (C, D; *P<0.05).
