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. 2018 May 21;11(5):dmm031005. doi: 10.1242/dmm.031005

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© 2018. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 1. — Hamartoma-like lesions form in the dorsal-central retina in Pten cKOs in the early postnatal period. (A,B) Flat-mount images of P21 wild-type (A) and Pten cKO (B) retinas. The dorsal-central retina is dysmorphic in Pten cKOs (red dashed line). (C-H) DAPI staining of transverse sections through the retinas of wild-type and Pten cKOs at P7 (C,D), P14 (E,F) and P21 (G,H). (I) Incidence of hamartoma-like lesions at P7, P14 and P21. (P7 wild-type: n=56, P7 Pten cKO: n=48, P14 wild-type: n=38, P14 Pten cKO: n=19, P21 wild-type: n=50, P21 Pten cKO: n=49.) D, dorsal; Ham, hamartoma; le, lens; N, nasal; nr, neural retina; ONH, optic nerve head; T, temporal; V, ventral. Scale bars: 200 μm.