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. Author manuscript; available in PMC: 2018 Jun 8.
Published in final edited form as: Psychopharmacology (Berl). 2016 Sep 13;233(23-24):3991–4002. doi: 10.1007/s00213-016-4425-4

Fig 1.

Fig 1

Animal weights (A) are represented on the day of surgery (implant) and at the end of each week for sham (open symbols) and oxycodone (filled symbols) adolescent (circles) and adult (triangles) exposure groups. The average (mean ± SEM) dose of oxycodone (B) is represented for the adolescent and adult exposure groups on the day of surgery and at the end of each week of exposure. Spontaneous somatic withdrawal score (C) 1, 2, and 3 days following sham and oxycodone exposure in adolescent and adult groups. Number sign indicates significant difference between age groups (###, p < 0.001) and asterisk indicates significant difference between drug exposure groups (***, p < 0.001)