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. Author manuscript; available in PMC: 2018 Jun 8.
Published in final edited form as: Psychopharmacology (Berl). 2016 Sep 13;233(23-24):3991–4002. doi: 10.1007/s00213-016-4425-4

Fig 4.

Fig 4

Locomotor sensitization to morphine is not affected by adolescent exposure to oxycodone. Locomotor activity (ambulations) recorded following the last saline baseline day (saline), the first injection 10 mg/kg morphine (acute), and following 4 daily injections of morphine and 1-week abstinence (challenge) are represented for adult mice exposed to sham (open circles; n = 6) and oxycodone (filled circles; n = 7) during adolescence. Both groups display a significant increase in ambulations over time (###, p < 0.01)