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. Author manuscript; available in PMC: 2018 Jun 8.
Published in final edited form as: Psychopharmacology (Berl). 2016 Sep 13;233(23-24):3991–4002. doi: 10.1007/s00213-016-4425-4

Fig 8.

Fig 8

Locomotor sensitization to morphine is not affected by adult exposure to oxycodone Locomotor activity (ambulations) recorded following the last saline baseline day (saline), the first injection of 10 mg/kg morphine (acute), and following 4 daily injections of morphine and 1-week abstinence (challenge) are represented for adult mice exposed to placebo (open triangles; n = 6) and oxycodone (filled triangles; n = 5) during adulthood. Both groups display a significant increase in ambulations on acute and challenge days as compared saline day (###, p < 0.001)