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. 2018 Jun 7;11:29. doi: 10.1186/s13072-018-0198-9

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — A model for SUV4-20 inhibition Upon SUV4-20 inhibition, K20me2 is demethylated to K20me1 if the molecule is not acetylated (or lightly acetylated). Meanwhile, SUV4-20 inhibition may also activate HAT activity through unknown mechanisms. This increases proteoforms containing K20me2 and multiple acetylations. The presence of multiple acetylations protects K20me2 from being demethylated