. 2017 Mar 1;2(1):3–12. doi: 10.1177/2396987316684705

Table 1.

Characteristics of included studies.

Studies	Number of Patients	Country	Time frame	Currency	Follow up	Additional info.	Average total cost per mRS (SD)
Studies	Number of Patients	Country	Time frame	Currency	Follow up	Additional info.	0	1	2	3	4	5	6
Asil et al.¹⁰	328	Turkey	January 2007– December 2007	USD	Discharge		1000 (729)			1838 (1895)			2777 (5792)
Baeten et al.¹¹	338	Netherlands	January 1999– January 2000	Euro	6 months	Stroke service	8400		11,080		29,644	27,371
					6 months	Usual Care	9856		14,868		37,682	46,089
					12 months	Usual Care	1761		4196		17,824	22,515
Christensen et al.¹²	820	Worldwide	May 2005– February 2007	USD	3 months		9466 (4614)	15,547 (7873)	18,742 (9978)	27,387 (11,621)	27,281 (8,919)	27,330 (11,495)	8136 (3719)
Christensen et al.¹²	820	Worldwide	May 2005– February 2007	USD	3 months	(95% CI)	7130– 11,902	13,336– 17,757	15,987– 21,496	24,372– 30,402	25,198– 29,364	22,182– 32,479	7421–9032
Christensen et al.¹³	167	Argentina	January 2004– August 2006	USD	Discharge	ICH	1475				6370
Christensen et al.¹³	167	Argentina	January 2004– August 2006	USD	Discharge	IS	1622				3188
Christensen et al.¹⁴	316	Brazil	January 2006– May 2007	USD	Discharge	ICH	6307					30,693
Christensen et al.¹⁴	316	Brazil	January 2006– May 2007	USD	Discharge	IS	1800				6771
Dawson et al.¹⁵	1717	Worldwide	March 1998– May 1999	GBP	3 months		2493 to 3412	3369 to 4479	5784 to 7008	7300 to 8515	10,095 to 11,141	11,772 to 13,560
Dodel et al.¹⁶	340	Germany	January 2000– June 2000	Euro	Discharge		3160 (1300)			4030 (2780)
Epifanov et al.¹⁷	253	Germany	January 1998– June 1998	Euro	Discharge		3,210 (2170)			3350 (3050)
Fattore et al.¹⁸	411	Italy	August 2005– March 2007	Euro	0–3 months		1225			3370	9185
					3–6 months		343			1688	2335
					6–12 months		513			939	2182
					12 month total		1964			5239	13,381
Hayes et al.¹⁹	172	USA	May 2001– September 2002	USD	3 months		7044	6159	7885	11,723	22,156	18,670
					3–12 months		4321	5727	3994	6811	5154	9958
					12 month total		14,901	12,637	12,751	23,218	30,971	28,628
Luengo-Fernandez et al.²⁰	153	United Kingdom	April 2002– March 2007	GBP	3 months		3945 (7558)			17,406 (18,417)		25,279 (16,396)
Luengo-Fernandez et al.²⁰	153	United Kingdom	April 2002– March 2007	GBP	Annual costs		2135 (3675)			4165 (7668)		6234 (14,898)
Spieler et al.²¹	435	France	Unavailable	Euro	18 months		10,255			17,457	31,728
Spieler et al.²¹	435	France	Unavailable	Euro	18 months	(95% CI)	9679–10,831			14,46– 020,453	28,811–34,645
Tanny et al.⁹	378	Australia	January 2003– December 2011	USD	3 months		29,406	32,214	36,205	37,878	39,522	41,780	16,727

Note: Tan Tanny et al, calculated hospital costs from 378 patients based on actual expenditure sourced from the Clinical costing unit of Royal Melbourne Hospital and inputted these costs in the cost effectiveness model of thrombolysis treatment.