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. 2018 Jun 7;16:157. doi: 10.1186/s12967-018-1533-4

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Relationship between the total voriconazole C_e/MIC and the intracellular antifungal effect as measured by the proportion of initial incubation. a The solid black line is the fit of an mathematical model to data from the infected A549 model, and the calculated equation by WinNonlin software is: effect index = 159.4 − 143.4 × (C_e/MIC)^1.1/(12.2^1.1 + (C_e/MIC)^1.1), R² = 0.9738. b The relationship between C_e/MIC breakpoint and intracellular antifungal effect