Table 2.
Dosage regimens | Probability of target attainment (%) at different minimum inhibitory concentrations | CFR (%) | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
0.03125 mg/L | 0.0625 mg/L | 0.125 mg/L | 0.25 mg/L | 0.5 mg/L | 1 mg/L | 2 mg/L | 4 mg/L | 8 mg/L | 16 mg/L | ||
100 mg/12 h, p.o. | 99.25 | 96.35 | 85.27 | 63.9 | 36.39 | 14.92 | 4.14 | 0.72 | 0.099 | 0.006 | 84.45 |
200 mg/12 h, p.o. | 99.65 | 98.21 | 92.94 | 80.01 | 58.78 | 34.15 | 15.28 | 4.92 | 1.15 | 0.21 | 91.48 |
300 mg/12 h, p.o. | 99.98 | 99.67 | 98.03 | 92.25 | 77.55 | 54.15 | 29.07 | 11.35 | 3.07 | 0.61 | 96.19 |
CFR cumulative fraction of response