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. 2018 Jun 1;5:60. doi: 10.3389/fcvm.2018.00060

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Copyright © 2018 Paone, Diofano, Park, Rottbauer and Just.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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GWAS and zebrafish: a powerful combination for cardiovascular research. The benefits of the zebrafish as an experimental system can enormously help to validate the functional relevance of candidate genes identified by GWA studies. In addition, the system enables the in vivo analysis of underlying pathomechanisms and is highly suitable for high throughput screening applications. In summary, the combination of GWAS and the zebrafish experimental system has the potential to lead to improved and specific therapeutic approaches.