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Inhibition of tumor necrosis factor (TNF)-α production by TAC and STA-21. Splenocytes of WT or lupus-prone NZB/WF1, Roquinsan/san, and MRL/lpr mice (n = 3) were cultured with TAC (1 nM) in the presence of LPS (100 ng/mL) for 3 days. TNF-α concentration in culture supernatants was determined by ELISA. *P < 0.05, ***P < 0.001 versus vehicle-treated condition. Data are mean ± SD.
