Figure 5.

Combination therapy with TAC and STA-21 reduced the population of GC B cells and plasma cells. Splenocytes of WT or lupus-prone MRL/lpr mice (n = 5) were cultured with TAC (1 nM) in the presence of LPS (100 ng/mL) for 3 days. After 3 days, cells were stained with antibodies against (a) B220⁺GL-7⁺ GC B cells and (b) B220^–CD138⁺ plasma cells for flow cytometric analysis. *P < 0.05, **P < 0.01. Data are mean ± SD.