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. 2018 Jun 7;6:48. doi: 10.1186/s40478-018-0548-7

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Effect of copy number alteration on MRNA and protein abundance. Frequency of significant correlations between CNA and mRNA (upper panel) or protein (middle panel) across all chromosomes. The heatmap (lower panel) indicates the copy number for each sample