Fig. 7.

EIF4F inhibitors reduce medulloblastoma cell viability. D556 at normal (10%FBS) and nutrient deprivation (2% FBS) conditions (a) and D556 and primary human cerebellar astrocytes cells (b) were treated with the EIF4F inhibitor 4EGI-1 for 72 h at the indicated concentrations. The 4EGI-1 toxic concentration in medulloblastoma D556 cells is considerably lower than in normal cerebellar astrocytes. Error bars indicate the standard deviation. c Treatment of D556 and primary human cerebellar astrocytes cells with 4EGI-1 in combination with cisplatin